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KMID : 0613820070170040561
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Journal of Life Science
2007 Volume.17 No. 4 p.561 ~ p.567
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Acute Toxicity of Leuconostoc kimchii GJ2, An Exopolysaccharide-Producing Lactic Acid Bacteria Isolated from Kimchi, in Mice
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Lee Jae-Joon
Lee Yu-Mi
Chang Hae-Choon
Lee Myong-Ryeol
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Abstract
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The present study was carried out to investigate the acute toxicity of Leuconostoc kimchii GJ2(Leu. kimchii GJ2), an exopolysaccharide-producing lactic acid bacteria isolated from kimchi, in ICR male and female mice. The test article was intraperitoneally or orally administered to both sexes of mice. Then followed a 14-day period of observation. In intraperitoneal acute toxicity test, mice were injected intraperitoneally with dosage of 0, 700, 900, 1,100, 1,300, 1,500, 1,700, 1,900, 2,100, 2,300 and 2,500 ㎎/㎏. Intraperitoneal 50% lethal doses(LD??) of Leu. kimchii GJ2 was ＞2,500 ㎎/㎏ in male and female mice. In oral acute toxicity test, male and female mice were gavaged with Leu. kimchii GJ2 of five doses(0, 625, 1,500, 2,500 and 5, 000 ㎎/㎏). Oral LD50 of Leu. kimchii GJ2 was consider to be higher than 5,000 ㎎/㎏. Furthermore, no significant changes in general conditions, body weights, clinical signs and any gross lesions were observed in both sexes of mice administered intraperitoneally or orally with Leu. kimchii GJ2. In conclusion, our results suggest that no adverse effect level of Leu. kimchii GJ2 is estimated to be over 2,500 ㎎/㎏ in the intraperitoneal route and 5,000 ㎎/㎏ in the oral route, respectively.
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KEYWORD
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Leuconostoc kimchii GJ2, exopolysaccharide-producing lactic acid bacteria, acute toxicity mice
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